In contrast, the KO (Alb–Cre+RBPJflox/floxRosa26mtmG/+) mice showed norrmal morphology in early embryonic development, but during the perinatal period and after birth, there was abnormal development of the bile ducts and emergence of intrahepatic cholestasis (Fig. 2F). Here, ALB is linked to intrahepatic cholestasis.