There were also significant gaps in data from regions such as Latin America, a predominance of data from sub-Saharan Africa, and large cohorts in Uganda, Cote D'Ivoire, and South Africa, and from older cohorts with more advanced immunodeficiency at ART initiation, which precluded an evaluation of the impact of initiating ART at higher CD4 counts. The gene discussed is CD4; the disease is immune system disorder.