Activation of the endothelium induces myosin-mediated contractions of endothelial cells (ECs), leading to the formation of intercellular gaps and subsequent extravasation of fluids, resulting in hypovolemia, edema, and organ dysfunction such as acute renal failure, acute respiratory distress syndrome (ARDS), and cerebral edema [7–10]. Here, MYH14 is linked to acute respiratory distress syndrome.