The aim of this study was to evaluate the ITH of the expression of several epithelial to mesenchymal transition (EMT) markers and PI3K/PTEN/Akt-pathway markers, as assessed by immunohistochemistry, and its relationship with standard histopathological prognosis parameters in a series of 40 CCRCC collected prospectively. This evidence concerns the gene PTEN and nonpapillary renal cell carcinoma.