PNPLA3 rs738409 2 risk alleles has been identified a risk factor for developing HCC associated with NAFLD [44], alcoholic liver disease [45] or chronic HCV infection [46, 47].The role of central obesity as a risk for HCC is also emerging as shown in a large European study [48]. The gene discussed is PNPLA3; the disease is metabolic dysfunction-associated steatotic liver disease.