CCND1 and cancer: For example, in terms of its anti-cancer bioactivity, resveratrol arrests the cell cycle progression of diverse cancer cell lines, which is the consequence of resveratrol binding to the RAC-α serine/threonine protein kinase (AKT) and triggering the PI3K/AKT/FOXO pathway, which is responsible for regulating the critical cell cycle controller cyclin D1 [3].