These proteins included leucine-rich α2 glycoprotein (LRG), apolipoprotein M (ApoM), complement C1q subcomponent (subunit B, C) (C1QB and C1QC), сomplement C1S (C1S), EGF-containing fibulin-like extracellular matrix protein 1 (fibulin-3, FIBL3), receptor-type tyrosine-protein phosphatase zeta (PTPRZ) and seizure protein 6 homolog (SEZ6), all displaying lower levels in AD compared to controls (Fig 6A–6H). This evidence concerns the gene C1S and Alzheimer disease.