CAT and central nervous system cancer: Fig 6 shows the results with intact and permeabilized T98G cells. The additions of BKA or CAT (25 μM of each, A, C) to intact cells had no effect on basal oxygen consumption, indicating that these compounds do not inhibit oxidative phosphorylation in intact glioma cells. As expected, the sequential addition of oligomycin resulted in significant inhibition of oxygen consumption. Experiments with digitonin-permeabilized T98G cells indicated that BKA and CAT (2.5 μM of each, B, D) were effective in fully inhibiting ADP-stimulated oxygen consumption.