Next, we analyzed invasive breast cancer using cancer genome databases MethHC41 and Cancer Browser.42 Comparing expression of the NEP promoter in breast cancer and normal tissue across a large number of invasive breast cancer samples (n=726) and normal controls (n=84) through the MethHC database revealed a statistically significant decrease in NEP mRNA expression in cancer samples (Figure 6a). Here, MME is linked to breast carcinoma.