MME and cancer: In a number of the studies concluding that NEP associates with increased metastasis and decreased survival, it is the stromal expression of NEP that predicts a poor prognosis.21, 22, 24, 33 In support of this, we observed that in high grade, metastatic IDC samples, NEP expression was decreased and predominately restricted to the stroma, compared with its epithelial expression in low-grade cancers (Figure 1d).