IL-6/STAT3 signaling in tumors often functions especially in tumor angiogenesis and influence on tumor-associated infiltrates.21, 22 With respect to tumor-infiltrating immune cells, elevated VEGF expression is correlated with highly enriched tumor-associated macrophage recruitment in breast cancer.23, 24 It has been reported that IL-6 and VEGF could be targets for several cancer therapies,25, 26 which pointed the crucial roles of IL-6 and VEGF in cancer research. This evidence concerns the gene VEGFA and breast cancer.