TNFRSF21 and neoplasm: DR6 overexpression in HEK293 cells leads to the activation of the nuclear factor-κB (NF-κB) pathway,3 and NF-κB-mediated signaling is required for the maintenance of DR6 expression in Jurkat leukemia cells,4 which suggests that DR6 may mediate inflammatory responses via NF-κB in tumor progression.