Mice that are genetically incapable of developing HFD-induced hyperinsulinemia show increased levels of UCP-1 in the white adipose tissue, but not in the BAT.24 Insulin resistance observed in Nesf/NUCB2-Tg mice may be partially attributable to the reduction in UCP-1 expression in the SWAT. This evidence concerns the gene NUCB2 and hyperinsulinism.