Therefore, this study aims to investigate the involvement of HMGCR in the development and progression of AD by studying the influence of HMGCR on neuroimaging biomarkers in the three different clinical stages (normal control (NC), mild cognitive impairment (MCI), AD) from the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset. This evidence concerns the gene HMGCR and early-onset autosomal dominant Alzheimer disease.