VEGFA and non-small cell lung carcinoma: These include the fibroblast growth factor receptors (FGFRs) family and their ligands, particularly FGF1 and FGF2, that induce the proliferation and migration of endothelial cells [20]; as well as the platelet-derived growth factor receptors (PDGFRs) and their ligands (PDGFs) that, either alone or in combination with FGF and VEGF, are associated with tumor vascularization in malignant disease, including NSCLC [21, 22] and the Ang-Tie-2 system [19, 22].