VEGFA and neoplasm: Furthermore, with Ang-2 being required to render endothelium responsive to VEGF and with both molecules contributing to tumor angiogenesis and metastases [84, 85], there seems to be a more encouraging response to the straightforward question of whether co-targeting of both ligands in a bispecific manner would improve the outcomes of current anti-angiogenic therapies [80, 83, 86–88].