Pirola and colleagues also showed that miR-122 mostly circulates in Ago2-free complexes in NAFLD patients and that its serum levels may constitute a better predictor of NAFLD severity when compared to classical disease biomarkers, including serum liver transaminases and caspase-cleaved cytokeratin-18 fragments [47]. Here, AGO2 is linked to metabolic dysfunction-associated steatotic liver disease.