H19 and hepatocellular carcinoma: Indeed, lncRNAs appear to mostly act as oncogenes in the liver; lncRNA H19 expression is highly increased in patients with hepatitis B virus (HBV)-induced HCC [15], and the newly-identified lncRNA high expression in HCC(HEIH) has been suggested to play a pivotal role in liver carcinogenesis, as its expression is significantly increased in HCC patients, particularly those with liver cirrhosis [16].