However, patients with optic neuritis and/or myelitis with non-organ specific antibodies (e.g., ANA) in serum, but without recognized systemic autoimmune disorder, tend to have NMO or NMOsd rather than “lupus myelitis” or “Sjogren-related myelopathy”, regardless of AQP4-IgG serological status [7,63]. This evidence concerns the gene AQP4 and optic neuritis.