TREM2 and age-related macular degeneration: In this study we initially characterized total miRNA expression in whole AMD retina, in a macular-enriched region of the AMD retina, and in ROS- (peroxide), IL-1β- and/or Aβ42-treated MG cells and found a significant up-regulation of an NF-kB-sensitive miRNA-34a closely linked to a down-regulation in a miRNA-34a mRNA target encoding TREM2 within the same tissue and cell samples.