NFKB1 and age-related macular degeneration: Several inducible miRNAs such as miRNA-34a are under transcriptional control by the pro-inflammatory transcription factor NF-kB in the CNS and other tissues, so up-regulated NF-kB, via increasing specific miRNA abundances, may ultimately act as an important down-regulator of the expression of multiple sporadic AMD-relevant genes [22,25,29,56,58,59].