TREM2 and age-related macular degeneration: At this point while the NF-kB-miRNA-34a-TREM2 circuit appears to be dysfunctional in AMD retina and in ROS- and cytokine-stressed MG cells we cannot exclude that other brain-enriched miRNAs have ancillary control on TREM2 mRNA stability and expression in the retina and CNS.