In the early stages of AMI, pathological changes such as myocardial ischemia, hypoxia, edema, and necrosis occur rapidly, followed by the release of necrotic products, such as cardiac troponins (cTns), creatine kinase (CK), and brain natriuretic peptide (BNP), into the bloodstream [16]. The gene discussed is NPPB; the disease is myocardial ischemia.