Univariate analyses showed that patients who developed CIN were more likely to be older (71.4 versus 62.1 years, P = 0.023), to have a history of diabetes (62.3% versus 35.8%, P = 0.011), to have hypertension (36.9% versus 22.4%, P = 0.031), to have received PCI (P = 0.014), to have received more CM (158 versus 78 mL, P = 0.002), and to be non-BNP-treated (P < 0.001). This evidence concerns the gene NPPB and cervical squamous intraepithelial neoplasia.