AKR1B10 and hepatocellular carcinoma: However, In non-digestive tract solid tumors such as lung cancer, breast cancer, and hepatocellular carcinoma, AKR1B10 are over-expressed and stimulates cell proliferation and migration by promoting lipid synthesis, activating the signaling molecule retinoic acid and transcription factor Nfr-2 that regulate cell proliferation and differentiation [39].