For these PI3K pathway inhibitors, we found that their interaction patterns can be classified into two categories: ibrutinib-driven (together with AKT and mTOR inhibitors MK-2206, everolimus and dactolisib), and PI3K inhibitor-driven (together with the CLL-approved PI3Kδ inhibitor idelalisib) (Fig. 6). This evidence concerns the gene AKT1 and B-cell chronic lymphocytic leukemia.