After adjusting for potential confounders (demographics, BMI, DM2, alcohol consumption, smoking status, total cholesterol, albumin, weight change, hypertension, heart disease, stroke, and claudication), a high level CML at baseline was associated with 10 % (95 % CI 5 %–15 %) higher incidence of a first ADL difficulty with a hazard ratio (HR) of 1.10 (95 % CI:1.05, 1.15), p < 0,01) per standard deviation (225 ng/mL CML). This evidence concerns the gene ALB and Hypertension.