Mice in which Lrp1 is selectively deleted from neurons exhibit prominent tremor and dystonia, behavioural abnormalities, hyperactivity, motor dysfunction, age-dependent dendritic spine degeneration, synapse loss, neuroinflammation, memory loss, eventual neurodegeneration, and premature death [169–171], clearly demonstrating that LRP1 is crucial to neuronal function. The gene discussed is LRP1; the disease is Tremor.