The Peroxisome Proliferator-Activated Receptor-γ (PPAR-γ) and its coactivator, the Peroxisome Proliferator-Activated Receptor-γ Coactivator-1 (PGC-1α), are important molecules in atherogenesis because they are associated with metabolic risk factors, such as obesity and diabetes [4, 5]. The gene discussed is PPARGC1A; the disease is Obesity.