Further, HMGB1 inhibited the growth of HMGB1-sensitive SW480 xenograft tumours in nude mice (Fig. 8a), whereas treatment with a combination therapy of HMGB1 and L-DON substantially inhibited the growth of HMGB1-resistant HT29 xenograft tumours (Fig. 8a). Here, HMGB1 is linked to neoplasm.