HMGB1 and neoplasm: On stimulation of activated human peripheral blood NK cells from healthy blood donors by agonistic anti-NK cell p30-related protein (Nkp30) mAbs, the NK cell-dependent cytotoxic effect on HT29 and HCT116 colon cancer cells was diminished by the HMGB1-specific inhibitor glycyrrhizin, indicating that HMGB1 was partly mediating the NK cell-triggered tumour cell death (Fig. 1d).