Several proteins have been reported so far to correlate with progression and/or metastases of LSCC tumors including the up-regulation of matrix metalloproteinases (MMPs) (Görögh et al. 2006; Uloza et al. 2011; Bodnar et al. 2014); cyclin D1 (CCND1) (Zhang et al. 2013; Jarmuz-Szymczak et al. 2013) or the downregulation of tumor suppressive proteins TSLC1 (Lu et al. 2012) or PCDH17 (Haruki et al. 2010; Giefing et al. 2011). This evidence concerns the gene CCND1 and neoplasm.