To determine whether disruption of microglial signalling through P2Y12 has functional consequences for ODP, we compared ocular dominance shifts following 4 days of MD in P2Y12WT animals treated with saline versus P2Y12WT animals treated with clopidogrel, P2Y12WT animals treated with ticagrelor or P2Y12KO animals. Here, P2RY12 is linked to Cooks syndrome.