AKR1B10 and metastatic malignant neoplasm in the lymph nodes: After analyzing the correlation of AKR1B10 mRNA expression in PHC tissues and the clinical data (Table 1), we found that AKR1B10 mRNA expression was correlated with serum alpha-fetoprotein (AFP) level, tumor-node-metastasis (TNM) stage, and lymph node metastasis, but not with other clinicopathologic variables, such as age and gender.