AKR1B10 and cancer: Growing evidence has confirmed that AKR1B10 is associated with the development and progression of many cancers such as hepatocellular carcinoma4, 5, 6, smoking-related non-small-cell lung cancer4, 7, 8, esophageal adenocarcinoma9, gastric cancer10, breast cancer11, cervical cancer12, and pancreatic cancer13.