After analyzing the correlation of AKR1B10 mRNA expression in PHC tissues and the clinical data (Table 1), we found that AKR1B10 mRNA expression was correlated with serum alpha-fetoprotein (AFP) level, tumor-node-metastasis (TNM) stage, and lymph node metastasis, but not with other clinicopathologic variables, such as age and gender. This evidence concerns the gene AFP and metastatic malignant neoplasm in the lymph nodes.