The P-glycoprotein (P-gp) modulator CyA is considered one of the most effective MDR-reversing agents15, but CyA may cause a wide range of side effects, including gingival hyperplasia, peptic ulcers, hypercholesterolemia, convulsions, immunosuppression, and nephrotoxicity16. This evidence concerns the gene PGP and familial hypercholesterolemia.