In both osteosarcoma (p = 1.4 × 10−3) and lung cancer models (p = 3.5 × 10−2; Figure S1C), we identified an association between mutation/deletion of CDKN2A and dependency upon the cyclin dependent kinase gene CDK11A, which encodes a CDKN2A interacting protein (Varjosalo et al., 2013). Here, CDK11A is linked to osteosarcoma.