CDKL5 and cancer: We also identified a series of dependencies between cancer driver genes and their transcriptional targets, the majority of which focused upon MYC. In lung cancer models, we found that MYC amplification was associated with an increased dependency upon CDKL5 (5.6 × 10−3; Figure 3H), a gene whose expression is regulated by MYC. Similarly, in esophageal models, we found MYC amplification to be associated with an increased dependency upon the MYC transcriptional target PRKCH (Zeller et al., 2006) (p = 6.7 × 10−3; Figure 3H).