PBRM1 and neoplasm: By grouping all tumor cell lines that had a loss-of-function mutation or homozygous deletion of any member of the SWI/SNF complex (including the genes ARID1A, SMARCA1, SMARCA4, ARID2, ARID1B, and PBRM1) and then carrying out MP tests on the siRNA data as before, we identified ten KGDs including TWF2 (Figure 5A), a gene encoding a protein that affects the stability of the actin cytoskeleton through interaction with G-actin (Pivovarova et al., 2013).