As an example of this, we selected for validation one of the KGDs associated with RB1 mutation in osteosarcoma (Kansara et al., 2014), DYRK1A (p = 6.8 × 10−3; Figure S3A), a component of the DREAM complex (Sadasivam and DeCaprio, 2013) previously identified as a protein interaction partner of RB1 (Varjosalo et al., 2013). This evidence concerns the gene DYRK1A and osteosarcoma.