PC and Hyperglycemia: Subordinate mice fed HFD also showed a downregulation in liver of expression of PEPCK and pyruvate carboxylase (PC) (Figure 2B; F(3,68) = 3.9, p < 0.05, F(3,68) =  3.38, p < 0.05, respectively), whereby excluding a significant role of gluconeogenesis on reported fasting hyperglycemia (Sanghez et al., 2013).