IKBKB and rheumatoid arthritis: Genes up-regulated in the IKKβ-competent cells were, as expected, enriched for pathways involved in immunity and inflammation, such as antigen processing and presentation, rheumatoid arthritis, and B cell receptor signaling pathway and allograft rejection, but intriguingly, genes down-regulated in the IKKβ-competent cells were enriched for focal adhesion, ECM-receptor interaction and, and the TGFβ signaling pathways (Table 2).