To increase power to detect associations of loci with glycemic status, we developed a “glycemic burden composite”, which involved meta-analysis of associations of four glycemic traits (fasting glucose, fasting insulin, fasting proinsulin, HbA1c) together with T2D risk and included over 2.5 million SNPs in the MAGIC and DIAGRAM consortia datasets. This evidence concerns the gene INS and type 2 diabetes mellitus.