A number of laboratory test parameters (acute phase reactants) may experience clear alterations during the active phases of RA, such as C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), interleukin 1β (IL-1β), interleukin 6 (IL-6) or TNFα (5,10). Here, TNF is linked to rheumatoid arthritis.