BDNF and early-onset autosomal dominant Alzheimer disease: The computations generated 15 pathways that were mostly involved in BS-I -mediated anti-AD effects: phagosome, endocytosis, neuroactive ligand-receptor interaction, Alzheimer's disease, calcium signaling pathway, MAPK signaling pathway, natural killer cell mediated cytotoxicity, Fc gamma R-mediated phagocytosis, antigen processing and presentation, hematopoietic cell lineage, chemokine signaling pathway, T cell receptor, Toll-like receptor, neurotrophin signaling pathways and apoptosis pathways (p < 0.05, Table 2).