(iii) After administration of various specific inhibitors for cellular signalling pathways, we found that Src, ERK and JKN signalling pathways mediates IL‐8‐up‐regulated cell motility activity, and that Src mediates IL‐8‐induced activation of EKR and JNK signalling pathways in human gastric cancer cells. The gene discussed is CXCL8; the disease is gastric cancer.