Moreover, according to previous studies that demonstrated the potential role of different molecules (PS100, SOX10, TRF2, CD10) in the aggressiveness and differentiation of cutaneous melanoma, we characterized the phenotype of the different circulating melanoma cell subpopulations using anti‐PS100, anti‐SOX10, anti‐TRF2, and anti‐CD10 antibodies 18, 19, 20, 21, 22, 23. Here, MME is linked to melanoma.