The downstream signaling transduction pathways of ROR1 are confusing, but a recent study, which focused on mAb and the hsRNA inhibitor ROR1, suggested that the PI3K/AKT/mTOR pathway might be involved.50 The findings of that study indicate that a cell survival signaling pathway, mediated by ROR1, may exist in NSCLC. The gene discussed is MTOR; the disease is non-small cell lung carcinoma.