Kallmann syndrome is a subgroup of CHH associated with a defective sense of smell (anosmia or hyposmia).1 When fertility is required, pulsatile GnRH infusion or combined human chorionic gonadotropin (HCG) and human menopausal gonadotropin (HMG) therapy may promote spermatogenesis.2 Combination of gonadotropins can also induce spermatogenesis in patients with acquired hypogonadotropic hypogonadism (HH) of various causes, such as surgery for pituitary tumors, sellar radiation, and sellar craniopharyngioma.3,4. Here, GNRH1 is linked to cartilage-hair hypoplasia.