PTGS2 and acute kidney injury: Thus, in addition to recent emphasis of NSAID related cardiovascular harm by U.S. Food and Drug Administration in 2015 followed by the existing label warning in 2005,15 our study used a nationwide, unselected Taiwanese population to further strengthen the adverse effects of NSAID on AKI, which were mostly observed in nonselective NSAID users not in COX-2 inhibitor users and extended results of previous studies on different races.