In a multivariate analysis, the NLR (HR = 4.62, p = 0.030), CRP (HR = 10.80, p = 0.045), and pathological lymph node metastasis (HR = 12.35, p = 0.009) were also found to be significantly associated with OS [Table 2]. This evidence concerns the gene CRP and metastatic malignant neoplasm in the lymph nodes.