TFRC and breast carcinoma: Considering the role of IRPs 1 and 2 in a situation of high iron levels, as expected in a breast cancer setting, IRP binding to 5′- untranslated region (UTR) of FT and lack of stabilization at the 3′-UTR of TFR1 would lead to an increased FT translation, with a concomitant decrease in TFR1.