TFRC and ductal breast carcinoma in situ: Lymphocytes had a significantly higher expression of hepcidin (p = 0.030) and TFR1 (p = 0.011) in DCIS in IDC (Fig. 6c), while macrophages from DCIS pure lesions exhibited a higher expression of FPN1 than DCIS in IDC (p = 0.036) (Fig. 6b).