Besides these trans-regulating lncRNAs, 402 lncRNAs in GBM affected genes located within 10 genes of the lncRNA in either direction, and only 19 lncRNAs affected more than two genes within this range (Figure 2D); these proportions are similar to those observed for randomly selected lncRNA-TF-gene triplets. The gene discussed is TF; the disease is glioblastoma.