However, a RNA polymerase I-specific transcription initiation factor (RRN3) and PDXDC1, a gene with carboxylase activity associated with diverse phenotypes including renal carcinoma [55] and sensorineural hearing loss [56] were also either proximate to or overlapping the peak in CMS1-FDR signal. This evidence concerns the gene PDXDC1 and sensorineural hearing loss disorder.