BRCA1 and neoplasm: BRCA1 mutant tumours harbouring truncating mutations (that probably led to a complete absence of protein through nonsense-mediated decay (NMD)) had a lower magnitude of expression of the immune genes compared to those harbouring missense mutations (resulting in an aberrant but still present BRCA1 protein) and this was underpinned by differing expression levels of the NFκB transcription factors [20].