TP53 and B-cell non-Hodgkin lymphoma: The above data indicate that p533KR/3KRXrcc4−/− mice show high levels of spontaneous genomic instability, but unlike p53−/−Xrcc4−/− mice that uniformlly succumb to pro-B-cell lymphomas by ∼10 weeks [19], p533KR/3KRXrcc4−/− mice lived up to 30 weeks (Figure 3A).