MAD2L1 and clear cell adenocarcinoma: In the Oslo cohort an inverse expression of miR-493-3p and Mad2 was observed; miR-493-3p expression was significantly reduced in advanced high-grade serous ovarian carcinoma (HGSC) compared to ovarian surface epithelium (OSE, p = 4.79e-09) and clear cell carcinomas (CCC, p = 3.79e-06) while Mad2 was significantly elevated in the HGSC versus OSE (p = 0.02, Figure 5A).