Our data demonstrate that anti-TNF-α treatment in the physiological range can reduce some of the cell-non-autonomous effects of the SASP; in particular, conditioned medium from senescent cells treated with adalimumab reduced the migration rate of MCF-7 breast cancer cells and strongly attenuated the mammospheres promoting effect of the senescent HUVECs secretome, suggesting a decreased pro-tumorigenic and pro-metastatic behavior of the SASP under TNF-α blockade condition. Here, TNF is linked to breast cancer.