ROCK1 and neoplasm: Taken together, studies described in Rock1-deficient mice, thus far, suggest that Rock1 may play an essential role in negatively regulating the survival of multiple hematopoietic lineages in the context of both inflammatory as well as oxidative stress in myeloid and erythroid cells, respectively, in part by regulating the activation of tumor-suppressor genes such as PTEN and p53.