PIN1 and lymphoma: A most interesting implication from these data is that pharmacological inhibition of Pin1 might lead to the proliferative arrest - and possibly elimination - of Myc-driven lymphomas: initial experiments with the Pin1 inhibitory compound PiB [51] were inconclusive, as this molecule showed off-target effects, inhibiting proliferation of Pin1-knockout as well as wild-type Eμ-myc tumors (data not shown).