To further assess how Pin1 influences p53 activity in lymphomas, we used tumors derived from Eμ-myc mice expressing p53ERTAM, a latent, OHT-inducible form of p53: as expected [43], OHT treatment induced an acute apoptotic response in those tumors, which was not affected by loss of Pin1 (Supplementary Figure 4C). The gene discussed is MYC; the disease is lymphoma.