Over the last years, NGS analyses in cSCC identified common gene alterations in TP53, NOTCH1, RAS, CDKN2A, AJUBA, CASP8, FAT1, KMT2C (MLL3), PIK3CA, SOX2 and CCND1 [7, 8]. The gene discussed is KMT2C; the disease is skin squamous cell carcinoma.